5-Valine-oxytocin and 1-Deamino-5-valine-oxytocin
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چکیده
منابع مشابه
Synthesis and Some Biological Properties and ll-Deamino=4=valine=oxytocin* of 4-Valine-oxytocin
4-Valine-oxytocin and 1-deamino-4-valine-oxytocin, analogues of the posterior pituitary hormone containing a valine residue in place of the glutamine residue in position 4, have been synthesized by the p-nitrophenyl ester method of peptide synthesis and tested for pharmacological activity. The 4-valine-oxytocin possesses 140 units per mg of oxytocic activity and 240 units per mg of avian vasode...
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Oxytocin, the main oxytocic-milk-ejecting-avian depressor principle of the posterior pituitary gland, the structure of which is shown in Fig. 1, possesses a number of chemical functional groups : a primary amino group in position 1, a phenolic hydroxyl group in position 2, three carboxamide groups in positions 4, 5, and 9, and a disulfide linkage in t.he 20.membered cyclic m0iet.y. The signific...
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This paper describes the synthesis and biological activity of [5-L-asparagine-alpha,beta,beta-d(3)]-deamino-oxytocin. The model peptide S-benzyl-beta-mercaptopropionyl-L- asparaginyl-alpha,beta,beta-d(3)-glycinamide was also prepared to observe the effect of the conditions of peptide synthesis on the deuterium content. It was found that normal synthetic procedures could be used without a signif...
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The leucine analogue 5',5',5',-trifluoroleucine (fluoroleucine) replaced leucine for repression of the isoleucine-valine biosynthetic enzymes in Salmonella typhimurium. In contrast, the analogue had no effect on derepression of the leucine biosynthetic enzymes in leucine auxotrophs grown on limiting amounts of leucine. The effect of fluoroleucine on repression appeared to be specific for leucin...
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A sensitive and precise method for assaying the water permeability response evoked by neurohypophyseal hormones and their synthetic analogues on the isolated urinary bladder of the toad (Bufo marinus L.) is described. The method permits detection of 8-arginine-vasotocin at concentrations as low as 10(-12)M. This sensitivity, not achieved heretofore with this tissue, results largely from minimiz...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1966
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)96370-2